FDA
No application listedNo application naming kisspeptin or metastin as an active ingredient is listed in Drugs@FDA. Checked 2026-10-05; the control lookup (semaglutide) returned 6 applications.
Drugs@FDA via openFDAKisspeptin-10: chemistry, literature and regulatory status
Research-use information. This page summarises published literature and regulator records. It is not guidance for use, not medical advice, and not a statement that any material is suitable for use in people or animals.
What is Kisspeptin-10?
Kisspeptin-10 is the C-terminal decapeptide Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 of the kisspeptins, the endogenous ligands of the G-protein-coupled receptor GPR54. Published work covers receptor discovery and receptor genetics. It is supplied here as a research material for laboratory use only.
What are the chemical facts for Kisspeptin-10?
- Name
- Kisspeptin-10
- Also written
- Metastin (45-54)
- Sequence
- Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2
- Length
- 10 residues
- Molecular formula
C63H83N17O14(matches the formula computed from the sequence)- Average molecular weight
- 1302.4 g/mol
- CAS number
374675-21-5(confirmed in PubChem)- PubChem
- CID 25240297
Chemistry checked against PubChem on 2026-10-05. Where the formula can be computed from the listed sequence, it was, and the two routes agree.
How does the literature describe the mechanism of Kisspeptin-10?
- Kisspeptins of 54, 14 and 13 amino acids were isolated from human placenta as natural agonists of the orphan receptor GPR54, with a common RF-amide C terminus.[2]
- The KiSS-1 gene product was identified as the peptide ligand of the orphan receptor, and a human receptor (AXOR12) was cloned and shown to be activated by KiSS-1 derived peptides.[4],[3]
- A genetic study in a human family and in mice linked GPR54 to the onset of puberty.[1]
What has published research on Kisspeptin-10 looked at?
4 studies are cited for Kisspeptin-10. Each is labelled by design below, and each entry says what the paper measured.
- 3 receptor biology
- 1 human genetics and animal study
PubMed returns 333 records for the search terms published on the method page (14 of them with a review publication type, 12 with a clinical-trial publication type), checked 5 October 2026. ClinicalTrials.gov lists 5 registered studies whose intervention matches the name (5 interventional), checked 5 October 2026.
Studies are listed by what they measured. Papers whose titles state an amount or schedule, or describe a clinical outcome of an approved medicine, are not listed. This is a wording rule, not a quality filter; see the method page.
What is the regulatory status of Kisspeptin-10?
EMA
No centrally authorised medicine listedNo centrally authorised procedure in the EMA medicines database (checked 5 October 2026) names kisspeptin as an active substance. National authorisations are not in this dataset.
EMA medicines dataMHRA
Name appears in text onlyThe exact name returns 5 MHRA Products documents; they mention the name in their text and were not assessed as products with it as an active substance. Checked 2026-10-05.
MHRA ProductsWADA
Named, S2.2.1The WADA 2026 Prohibited List, in force 1 January 2026 names kisspeptin under S2.2.1 (testosterone-stimulating peptides in males). A WADA entry is a sporting rule, not a statement about legality outside sport.
WADA Prohibited List 2026The WADA 2026 list names kisspeptin and its agonist analogues under S2.2.1.
A regulator record is information about a database entry. It is not advice and not a statement that any use is lawful or unlawful in any country. How regulators approach research peptides.
Data dates: regulatory records 2026-10-05; WADA list 2026-10-05.
Which studies are cited for Kisspeptin-10?
[1] Seminara SB, Messager S, Chatzidaki EE, Thresher RR, Acierno JS, Shagoury JK, et al.. The GPR54 gene as a regulator of puberty. N Engl J Med. 2003;349:1614-27.
Genetic study in a human family and in mice linking GPR54 to the onset of puberty.
[2] Kotani M, Detheux M, Vandenbogaerde A, Communi D, Vanderwinden JM, Le Poul E, et al.. The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J Biol Chem. 2001;276:34631-6.
Isolation of kisspeptins from human placenta as ligands of GPR54, with receptor binding and signalling in cells.
[3] Muir AI, Chamberlain L, Elshourbagy NA, Michalovich D, Moore DJ, Calamari A, et al.. AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1. J Biol Chem. 2001;276:28969-75.
Cloned the human receptor AXOR12 (GPR54) and showed its activation by KiSS-1 derived peptides.
[4] Ohtaki T, Shintani Y, Honda S, Matsumoto H, Hori A, Kanehashi K, et al.. Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature. 2001;411:613-7.
Identified the KiSS-1 gene product peptide as the ligand of an orphan G-protein-coupled receptor and measured receptor activation.
Data dates: citations read from PubMed 2026-10-05.
Where else in the research library is Kisspeptin-10 covered?
Who wrote this page and how is it checked?
Peptency editorial team, last reviewed 5 October 2026. Citations are read back from PubMed, chemistry is checked against PubChem, and regulator records are read from each regulator's own database on the dates shown. The method page lists every source, search term and rule. Corrections are welcome through the contact details on the About page.