{ "schema": "peptency.research.citations/1", "description": "Every study cited in the Peptency research library, read back from PubMed. Titles are reproduced as indexed (a double hyphen in a title is shown as a colon).", "notice": "Research-use information. This library summarises published literature and regulator records. It is not guidance for use, not medical advice, and not a statement that any material is suitable for use in people or animals.", "verifiedOn": "2026-10-05", "source": "PubMed E-utilities (efetch)", "count": 109, "studies": [ { "pmid": "42794771", "title": "BPC 157 in Rodent Ischemia-Reperfusion Injury: A Critical Review of Preclinical Evidence.", "authors": [ "Demirtaş H" ], "journal": "International journal of molecular sciences", "journalAbbreviation": "Int J Mol Sci", "year": 2026, "volume": "27", "pages": null, "doi": "10.3390/ijms27188344", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42794771/", "doiUrl": "https://doi.org/10.3390/ijms27188344", "design": "Review", "whatItMeasured": "Critical review of preclinical evidence for BPC 157 in rodent ischaemia-reperfusion models, with attention to oxidative stress and endothelial nitric-oxide responses.", "corrections": [], "citedOnCompounds": [ "bpc-157" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/bpc-157/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/bpc-157/" } }, { "pmid": "42745421", "title": "Detection and Excretion Profile of Retatrutide in Human Plasma and Urine by LC-HRMS: Implications for Antidoping Analysis.", "authors": [ "Carneiro GRA", "da Costa Nunes IK", "Dos Santos Cardoso GR", "Dos Santos PF", "Padilha MC", "Nogueira FCS", "Pereira HMG" ], "journal": "Rapid communications in mass spectrometry : RCM", "journalAbbreviation": "Rapid Commun Mass Spectrom", "year": 2026, "volume": "40", "pages": "e70179", "doi": "10.1002/rcm.70179", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42745421/", "doiUrl": "https://doi.org/10.1002/rcm.70179", "design": "Analytical chemistry", "whatItMeasured": "LC-HRMS detection and excretion profile of retatrutide in human plasma and urine, for anti-doping analysis.", "corrections": [], "citedOnCompounds": [ "retatrutide" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/retatrutide/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/retatrutide/" } }, { "pmid": "42630988", "title": "Comparative effects of semaglutide tirzepatide and retatrutide on renal fibrosis in UUO and aged mice.", "authors": [ "Ding M", "Li X", "Wei Y", "Wang J", "Jiao B", "Li C", "Ma W", "Peng Y", "Shen J", "Yu G", "Gao C" ], "journal": "iScience", "journalAbbreviation": "iScience", "year": 2026, "volume": "29", "pages": "117174", "doi": "10.1016/j.isci.2026.117174", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42630988/", "doiUrl": "https://doi.org/10.1016/j.isci.2026.117174", "design": "In vitro and animal study", "whatItMeasured": "Compared semaglutide, tirzepatide and retatrutide in human kidney cells and in mouse models of renal fibrosis and ageing.", "corrections": [], "citedOnCompounds": [ "retatrutide" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/retatrutide/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/retatrutide/" } }, { "pmid": "42611943", "title": "MOTS-c is a mitochondrial-encoded interferon-linked host defense peptide.", "authors": [ "Rice MC", "Imun M", "Jung SW", "Park CY", "Kim JS", "Lai RW", "Barr CR", "Son JM", "Tor K", "Kim E", "Lu RJ", "Cohen I", "Benayoun BA", "Lee C" ], "journal": "eLife", "journalAbbreviation": "Elife", "year": 2026, "volume": "12", "pages": null, "doi": "10.7554/eLife.87615", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42611943/", "doiUrl": "https://doi.org/10.7554/eLife.87615", "design": "In vitro and animal study", "whatItMeasured": "Identified MOTS-c as a mitochondria-encoded host defense peptide and tested its antimicrobial and interferon-linked activity.", "corrections": [], "citedOnCompounds": [ "mots-c" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/mots-c/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/mots-c/" } }, { "pmid": "42542926", "title": "Effects of BPC-157 and TB-500 on Achilles tendon healing in rats: A histopathological and biomechanical study.", "authors": [ "Biçer O", "Adanir O", "Güleryüz Y", "Balci EC", "Dinçel YM", "Yenigün MY", "Aydin C", "Bayrak BY" ], "journal": "Joint diseases and related surgery", "journalAbbreviation": "Jt Dis Relat Surg", "year": 2026, "volume": "37", "pages": "822-837", "doi": "10.52312/jdrs.2026.2951", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42542926/", "doiUrl": "https://doi.org/10.52312/jdrs.2026.2951", "design": "Animal study", "whatItMeasured": "Compared BPC-157, synthetic thymosin beta 4 (TB-500) and their combination in a rat Achilles tendon model with biomechanical and histological analyses.", "corrections": [], "citedOnCompounds": [ "tb-500" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/tb-500/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/tb-500/" } }, { "pmid": "42485063", "title": "Comprehensive characterization of bremelanotide acetate and its degradants by LC-HRMS/MS and predicting epimerization through computational modelling.", "authors": [ "Yuvaraaj VK", "Sharma N" ], "journal": "Analytical methods : advancing methods and applications", "journalAbbreviation": "Anal Methods", "year": 2026, "volume": "18", "pages": "6968-6982", "doi": "10.1039/d6ay01098a", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42485063/", "doiUrl": "https://doi.org/10.1039/d6ay01098a", "design": "Analytical chemistry", "whatItMeasured": "Stability-indicating RP-HPLC method and LC-HRMS/MS characterisation of bremelanotide degradation products.", "corrections": [], "citedOnCompounds": [ "pt-141" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/pt-141/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/pt-141/" } }, { "pmid": "42340853", "title": "Goldilocks-Inspired Design of Mid-Size Macrocycles for Selective Targeting of Human Melanocortin Receptors.", "authors": [ "Merlino F", "Jia L", "Boccino I", "Carotenuto A", "Tammaro F", "Santoro F", "Thompson PE", "Grieco P" ], "journal": "Journal of medicinal chemistry", "journalAbbreviation": "J Med Chem", "year": 2026, "volume": "69", "pages": "18800-18812", "doi": "10.1021/acs.jmedchem.6c01074", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42340853/", "doiUrl": "https://doi.org/10.1021/acs.jmedchem.6c01074", "design": "Chemistry", "whatItMeasured": "Design of mid-size macrocycles for selective melanocortin-receptor targeting, with bremelanotide and setmelanotide as reference macrocycles.", "corrections": [], "citedOnCompounds": [ "pt-141" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/pt-141/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/pt-141/" } }, { "pmid": "42067476", "title": "Emerging opportunities for nicotinamide N-methyltransferase (NNMT) inhibitor clinical translation.", "authors": [ "Puleo N", "Allega MF", "Niemann CU", "Lengyel E" ], "journal": "Trends in pharmacological sciences", "journalAbbreviation": "Trends Pharmacol Sci", "year": 2026, "volume": "47", "pages": "638-654", "doi": "10.1016/j.tips.2026.04.002", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/42067476/", "doiUrl": "https://doi.org/10.1016/j.tips.2026.04.002", "design": "Review", "whatItMeasured": "Review of opportunities and obstacles for clinical translation of NNMT inhibitors.", "corrections": [], "citedOnCompounds": [ "5-amino-1mq" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/5-amino-1mq/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/5-amino-1mq/" } }, { "pmid": "41606641", "title": "BPC157 drives angiogenesis through FBXO22-dependent stabilization of BACH1.", "authors": [ "Zhang J", "Liu M", "Ou H", "Wang Z", "He L", "Xiao Y", "Xie F", "Yu D", "Cao H", "He W", "Wang S", "Zhang W", "Zhang K", "Zhang Y", "Li M", "Hao Q" ], "journal": "Cell communication and signaling : CCS", "journalAbbreviation": "Cell Commun Signal", "year": 2026, "volume": "24", "pages": null, "doi": "10.1186/s12964-026-02694-6", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/41606641/", "doiUrl": "https://doi.org/10.1186/s12964-026-02694-6", "design": "In vitro and animal study", "whatItMeasured": "Investigated the molecular mechanism of the pro-angiogenic effect of BPC157, reporting an FBXO22 and BACH1 pathway.", "corrections": [], "citedOnCompounds": [ "bpc-157" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/bpc-157/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/bpc-157/" } }, { "pmid": "41171324", "title": "The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons.", "authors": [ "Kolbaev SN", "Sharonova IN", "Skrebitsky VG" ], "journal": "Bulletin of experimental biology and medicine", "journalAbbreviation": "Bull Exp Biol Med", "year": 2025, "volume": "179", "pages": "416-420", "doi": "10.1007/s10517-025-06501-z", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/41171324/", "doiUrl": "https://doi.org/10.1007/s10517-025-06501-z", "design": "In vitro", "whatItMeasured": "Measured intracellular calcium dynamics in rat hippocampal and cerebellar slices exposed to Semax.", "corrections": [], "citedOnCompounds": [ "semax" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/semax/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/semax/" } }, { "pmid": "40908429", "title": "Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.", "authors": [ "Al-Dulaimi S", "Thomas R", "Matta S", "Roberts T" ], "journal": "Biogerontology", "journalAbbreviation": "Biogerontology", "year": 2025, "volume": "26", "pages": "178", "doi": "10.1007/s10522-025-10315-x", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/40908429/", "doiUrl": "https://doi.org/10.1007/s10522-025-10315-x", "design": "In vitro", "whatItMeasured": "Measured telomere length and telomerase activity in human cell lines exposed to epitalon. A correction notice has been published for this paper.", "corrections": [ { "kind": "ErratumIn", "source": "Biogerontology. 2025 Nov 15;27(1):1. doi: 10.1007/s10522-025-10326-8.", "pmid": "41240216" } ], "citedOnCompounds": [ "epitalon" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/epitalon/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/epitalon/" } }, { "pmid": "40789979", "title": "Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing.", "authors": [ "McGuire FP", "Martinez R", "Lenz A", "Skinner L", "Cushman DM" ], "journal": "Current reviews in musculoskeletal medicine", "journalAbbreviation": "Curr Rev Musculoskelet Med", "year": 2025, "volume": "18", "pages": "611-619", "doi": "10.1007/s12178-025-09990-7", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/40789979/", "doiUrl": "https://doi.org/10.1007/s12178-025-09990-7", "design": "Review", "whatItMeasured": "Scoping review of BPC-157 mechanisms, preclinical and clinical data and safety concerns in musculoskeletal research, noting its regulatory status.", "corrections": [], "citedOnCompounds": [ "bpc-157" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/bpc-157/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/bpc-157/" } }, { "pmid": "40756949", "title": "Emerging Use of BPC-157 in Orthopaedic Sports Medicine: A Systematic Review.", "authors": [ "Vasireddi N", "Hahamyan H", "Salata MJ", "Karns M", "Calcei JG", "Voos JE", "Apostolakos JM" ], "journal": "HSS journal : the musculoskeletal journal of Hospital for Special Surgery", "journalAbbreviation": "HSS J", "year": 2025, "volume": "21", "pages": "485-495", "doi": "10.1177/15563316251355551", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/40756949/", "doiUrl": "https://doi.org/10.1177/15563316251355551", "design": "Systematic review", "whatItMeasured": "Systematic review of BPC-157 reports in orthopaedic sports medicine.", "corrections": [], "citedOnCompounds": [ "bpc-157" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/bpc-157/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/bpc-157/" } }, { "pmid": "40650034", "title": "Genes That Associated with Action of ACTH-like Peptides with Neuroprotective Potential in Rat Brain Regions with Different Degrees of Ischemic Damage.", "authors": [ "Filippenkov IB", "Shpetko YY", "Ales DA", "Stavchansky VV", "Denisova AE", "Yuzhakov VV", "Fomina NK", "Gubsky LV", "Andreeva LA", "Myasoedov NF", "Limborska SA", "Dergunova LV" ], "journal": "International journal of molecular sciences", "journalAbbreviation": "Int J Mol Sci", "year": 2025, "volume": "26", "pages": null, "doi": "10.3390/ijms26136256", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/40650034/", "doiUrl": "https://doi.org/10.3390/ijms26136256", "design": "Animal study", "whatItMeasured": "Analysed gene expression (RNA-Seq) in rat brain regions after ACTH-like peptides including Semax.", "corrections": [], "citedOnCompounds": [ "semax" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/semax/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/semax/" } }, { "pmid": "40496623", "title": "Semax, a Copper Chelator Peptide, Decreases the Cu(II)-Catalyzed ROS Production and Cytotoxicity of aβ by Metal Ion Stripping and Redox Silencing.", "authors": [ "Tomasello MF", "Di Rosa MC", "Naletova I", "Sciacca MFM", "Giuffrida A", "Maccarrone G", "Attanasio F" ], "journal": "Bioinorganic chemistry and applications", "journalAbbreviation": "Bioinorg Chem Appl", "year": 2025, "volume": "2025", "pages": "4226220", "doi": "10.1155/bca/4226220", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/40496623/", "doiUrl": "https://doi.org/10.1155/bca/4226220", "design": "Chemistry and in vitro study", "whatItMeasured": "Examined copper(II) binding by Semax and its effect on Cu(II)-catalysed reactive oxygen species production and amyloid-beta cytotoxicity.", "corrections": [], "citedOnCompounds": [ "semax" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/semax/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/semax/" } }, { "pmid": "40141333", "title": "Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.", "authors": [ "Araj SK", "Brzezik J", "Mądra-Gackowska K", "Szeleszczuk Ł" ], "journal": "International journal of molecular sciences", "journalAbbreviation": "Int J Mol Sci", "year": 2025, "volume": "26", "pages": null, "doi": "10.3390/ijms26062691", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/40141333/", "doiUrl": "https://doi.org/10.3390/ijms26062691", "design": "Review", "whatItMeasured": "Overview of in vitro, in vivo and in silico studies of epitalon.", "corrections": [], "citedOnCompounds": [ "epitalon" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/epitalon/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/epitalon/" } }, { "pmid": "40005999", "title": "Multifunctionality and Possible Medical Application of the BPC 157 Peptide-Literature and Patent Review.", "authors": [ "Józwiak M", "Bauer M", "Kamysz W", "Kleczkowska P" ], "journal": "Pharmaceuticals (Basel, Switzerland)", "journalAbbreviation": "Pharmaceuticals (Basel)", "year": 2025, "volume": "18", "pages": null, "doi": "10.3390/ph18020185", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/40005999/", "doiUrl": "https://doi.org/10.3390/ph18020185", "design": "Review", "whatItMeasured": "Literature and patent review of preclinical reports on BPC 157.", "corrections": [], "citedOnCompounds": [ "bpc-157" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/bpc-157/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/bpc-157/" } }, { "pmid": "38994967", "title": "Thymosin β4 and β10 Expression in Human Organs during Development: A Review.", "authors": [ "Faa G", "Messana I", "Coni P", "Piras M", "Pichiri G", "Piludu M", "Iavarone F", "Desiderio C", "Vento G", "Tirone C", "Manconi B", "Olianas A", "Contini C", "Cabras T", "Castagnola M" ], "journal": "Cells", "journalAbbreviation": "Cells", "year": 2024, "volume": "13", "pages": null, "doi": "10.3390/cells13131115", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/38994967/", "doiUrl": "https://doi.org/10.3390/cells13131115", "design": "Human tissue study (review)", "whatItMeasured": "Review of the authors' proteomic and tissue data on thymosin beta 4 and beta 10 expression across human organs during development.", "corrections": [], "citedOnCompounds": [ "tb-500" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/tb-500/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/tb-500/" } }, { "pmid": "38149577", "title": "Immune modulation via dendritic cells by the effect of Thymosin-alpha-1 on immune synapse in HCMV infection.", "authors": [ "Espinar-Buitrago MS", "Vazquez-Alejo E", "Magro-Lopez E", "Tarancon-Diez L", "Leal M", "Muñoz-Fernandez MA" ], "journal": "International immunopharmacology", "journalAbbreviation": "Int Immunopharmacol", "year": 2023, "volume": "125", "pages": "111103", "doi": "10.1016/j.intimp.2023.111103", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/38149577/", "doiUrl": "https://doi.org/10.1016/j.intimp.2023.111103", "design": "In vitro", "whatItMeasured": "Examined thymosin alpha 1 effects on dendritic cells and the immune synapse in a cell culture model of human cytomegalovirus infection.", "corrections": [], "citedOnCompounds": [ "thymosin-alpha-1" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/thymosin-alpha-1/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/thymosin-alpha-1/" } }, { "pmid": "37806509", "title": "Cationic exchange SPE combined with triple quadrupole UHPLC-MS/MS for detection of GHRHs in urine samples.", "authors": [ "Cristea CD", "Radu M", "Toboc A", "Stan C", "David V" ], "journal": "Analytical biochemistry", "journalAbbreviation": "Anal Biochem", "year": 2023, "volume": "682", "pages": "115336", "doi": "10.1016/j.ab.2023.115336", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/37806509/", "doiUrl": "https://doi.org/10.1016/j.ab.2023.115336", "design": "Analytical chemistry", "whatItMeasured": "UHPLC-MS/MS method for detecting GHRH analogues in urine for anti-doping analysis.", "corrections": [], "citedOnCompounds": [ "tesamorelin" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/tesamorelin/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/tesamorelin/" } }, { "pmid": "37295337", "title": "Assessment of anterior pituitary reserve capacity based on growth hormone response to growth hormone-releasing peptide-2 test in the elderly.", "authors": [ "Teramoto S", "Tahara S", "Hattori Y", "Kondo A", "Morita A" ], "journal": "Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society", "journalAbbreviation": "Growth Horm IGF Res", "year": 2023, "volume": "71", "pages": "101545", "doi": "10.1016/j.ghir.2023.101545", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/37295337/", "doiUrl": "https://doi.org/10.1016/j.ghir.2023.101545", "design": "Human study", "whatItMeasured": "Analysed growth hormone response to the GHRP-2 diagnostic test in 65 elderly patients with a non-functioning pituitary tumour.", "corrections": [], "citedOnCompounds": [ "ghrp-2" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ghrp-2/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ghrp-2/" } }, { "pmid": "37175390", "title": "The Pathophysiological Role of Thymosin β4 in the Kidney Glomerulus.", "authors": [ "Mason WJ", "Vasilopoulou E" ], "journal": "International journal of molecular sciences", "journalAbbreviation": "Int J Mol Sci", "year": 2023, "volume": "24", "pages": null, "doi": "10.3390/ijms24097684", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/37175390/", "doiUrl": "https://doi.org/10.3390/ijms24097684", "design": "Review", "whatItMeasured": "Review of thymosin beta 4 in kidney glomerular cells and glomerular disease models.", "corrections": [], "citedOnCompounds": [ "tb-500" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/tb-500/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/tb-500/" } }, { "pmid": "36291616", "title": "Ligands for Melanocortin Receptors: Beyond Melanocyte-Stimulating Hormones and Adrenocorticotropin.", "authors": [ "Yuan XC", "Tao YX" ], "journal": "Biomolecules", "journalAbbreviation": "Biomolecules", "year": 2022, "volume": "12", "pages": null, "doi": "10.3390/biom12101407", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/36291616/", "doiUrl": "https://doi.org/10.3390/biom12101407", "design": "Review", "whatItMeasured": "Review of melanocortin receptor ligands beyond melanocyte-stimulating hormones and ACTH.", "corrections": [], "citedOnCompounds": [ "pt-141" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/pt-141/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/pt-141/" } }, { "pmid": "35921984", "title": "Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue.", "authors": [ "Samms RJ", "Zhang G", "He W", "Ilkayeva O", "Droz BA", "Bauer SM", "Stutsman C", "Pirro V", "Collins KA", "Furber EC", "Coskun T", "Sloop KW", "Brozinick JT", "Newgard CB" ], "journal": "Molecular metabolism", "journalAbbreviation": "Mol Metab", "year": 2022, "volume": "64", "pages": "101550", "doi": "10.1016/j.molmet.2022.101550", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/35921984/", "doiUrl": "https://doi.org/10.1016/j.molmet.2022.101550", "design": "Animal study", "whatItMeasured": "Measured amino-acid profiles in brown 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II with scaffold chemistry and profiled functional selectivity at human melanocortin receptors.", "corrections": [], "citedOnCompounds": [ "melanotan-ii" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/melanotan-ii/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/melanotan-ii/" } }, { "pmid": "34665524", "title": "Advances in the detection of growth hormone releasing hormone synthetic analogs.", "authors": [ "Memdouh S", "Gavrilović I", "Ng K", "Cowan D", "Abbate V" ], "journal": "Drug testing and analysis", "journalAbbreviation": "Drug Test Anal", "year": 2021, "volume": "13", "pages": "1871-1887", "doi": "10.1002/dta.3183", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/34665524/", "doiUrl": "https://doi.org/10.1002/dta.3183", "design": "Analytical chemistry", "whatItMeasured": "Review and validation of methods to detect synthetic GHRH analogues in anti-doping samples; notes their WADA prohibition.", "corrections": [], "citedOnCompounds": [ "cjc-1295-no-dac" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/cjc-1295-no-dac/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/cjc-1295-no-dac/" } }, { "pmid": "34458733", "title": "Mechanisms and inhibitors of nicotinamide N-methyltransferase.", "authors": [ "Iyamu ID", "Huang R" ], "journal": "RSC medicinal chemistry", "journalAbbreviation": "RSC Med Chem", "year": 2021, "volume": "12", "pages": "1254-1261", "doi": "10.1039/d1md00016k", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/34458733/", "doiUrl": "https://doi.org/10.1039/d1md00016k", "design": "Review", "whatItMeasured": "Review of NNMT mechanisms and inhibitor development.", "corrections": [], "citedOnCompounds": [ "5-amino-1mq" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/5-amino-1mq/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/5-amino-1mq/" } }, { "pmid": "34433901", "title": "Structural insights into ligand recognition and activation of the melanocortin-4 receptor.", "authors": [ "Zhang H", "Chen LN", "Yang D", "Mao C", "Shen Q", "Feng W", "Shen DD", "Dai A", "Xie S", "Zhou Y", "Qin J", "Sun JP", "Scharf DH", "Hou T", "Zhou T", "Wang MW", "Zhang Y" ], "journal": "Cell research", "journalAbbreviation": "Cell Res", "year": 2021, "volume": "31", "pages": "1163-1175", "doi": "10.1038/s41422-021-00552-3", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/34433901/", "doiUrl": "https://doi.org/10.1038/s41422-021-00552-3", "design": "Structural biology", "whatItMeasured": "Cryo-EM structures of full-length human MC4R bound to alpha-MSH, afamelanotide, bremelanotide and a small-molecule ligand.", "corrections": [], "citedOnCompounds": [ "pt-141" ], "pageUrl": { "us": 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"https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/5-amino-1mq/" } }, { "pmid": "33353981", "title": "NAD+ metabolism and its roles in cellular processes during ageing.", "authors": [ "Covarrubias AJ", "Perrone R", "Grozio A", "Verdin E" ], "journal": "Nature reviews. Molecular cell biology", "journalAbbreviation": "Nat Rev Mol Cell Biol", "year": 2021, "volume": "22", "pages": "119-141", "doi": "10.1038/s41580-020-00313-x", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/33353981/", "doiUrl": "https://doi.org/10.1038/s41580-020-00313-x", "design": "Review", "whatItMeasured": "Review of NAD+ metabolism and the roles of NAD+-dependent enzymes (sirtuins, CD38, PARPs) in cellular processes during ageing.", "corrections": [], "citedOnCompounds": [ "nad-plus" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/nad-plus/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/nad-plus/" } }, { "pmid": "32730231", "title": "Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist.", "authors": [ "Willard FS", "Douros JD", "Gabe MB", "Showalter AD", "Wainscott DB", "Suter TM", "Capozzi ME", "van der Velden WJ", "Stutsman C", "Cardona GR", "Urva S", "Emmerson PJ", "Holst JJ", "D'Alessio DA", "Coghlan MP", "Rosenkilde MM", "Campbell JE", "Sloop KW" ], "journal": "JCI insight", "journalAbbreviation": "JCI Insight", "year": 2020, "volume": "5", "pages": null, "doi": "10.1172/jci.insight.140532", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32730231/", "doiUrl": "https://doi.org/10.1172/jci.insight.140532", "design": "In vitro", "whatItMeasured": "Measured receptor binding and signalling of tirzepatide at the GIP and GLP-1 receptors, reporting imbalanced and biased agonism.", "corrections": [], "citedOnCompounds": [ "tirzepatide" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/tirzepatide/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/tirzepatide/" } }, { "pmid": "32694684", "title": "NAD+ homeostasis in health and disease.", "authors": [ "Katsyuba E", "Romani M", "Hofer D", "Auwerx J" ], "journal": "Nature metabolism", "journalAbbreviation": "Nat Metab", "year": 2020, "volume": "2", "pages": "9-31", "doi": "10.1038/s42255-019-0161-5", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32694684/", "doiUrl": "https://doi.org/10.1038/s42255-019-0161-5", "design": "Review", "whatItMeasured": "Review of NAD+ homeostasis, biosynthesis pathways and sirtuin signalling.", "corrections": [], "citedOnCompounds": [ "nad-plus" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/nad-plus/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/nad-plus/" } }, { "pmid": "32342318", "title": "Functional Connectomic Approach to Studying Selank and Semax Effects.", "authors": [ "Panikratova YR", "Lebedeva IS", "Sokolov OY", "Rumshiskaya AD", "Kupriyanov DA", "Kost NV", "Myasoedov NF" ], "journal": "Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections", "journalAbbreviation": "Dokl Biol Sci", "year": 2020, "volume": "490", "pages": "9-11", "doi": "10.1134/S001249662001007X", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/32342318/", "doiUrl": "https://doi.org/10.1134/S001249662001007X", "design": "Human study", "whatItMeasured": "Measured whole-brain resting-state functional connectivity in 52 healthy participants for Selank and Semax.", "corrections": [], "citedOnCompounds": [ "selank" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/selank/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/selank/" } }, { "pmid": "31667971", "title": "The occurrence of putative cognitive enhancing research peptides in seized pharmaceutical preparations: An incentive for controlling agencies to prepare for future encounters of the kind.", "authors": [ "Vanhee C", "Francotte A", "Janvier S", "Deconinck E" ], "journal": "Drug testing and analysis", "journalAbbreviation": "Drug Test Anal", "year": 2020, "volume": "12", "pages": "371-381", "doi": "10.1002/dta.2717", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/31667971/", "doiUrl": "https://doi.org/10.1002/dta.2717", "design": "Analytical chemistry", "whatItMeasured": "Identification of Selank and Semax in seized pharmaceutical preparations by analytical methods. The authors state that neither has completed clinical trials, to their knowledge.", "corrections": [], "citedOnCompounds": [ "selank" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/selank/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/selank/" } }, { "pmid": "31625062", "title": "Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats.", "authors": [ "Kolik LG", "Nadorova AV", "Antipova TA", "Kruglov SV", "Kudrin VS", "Durnev AD" ], "journal": "Bulletin of experimental biology and medicine", "journalAbbreviation": "Bull Exp Biol Med", "year": 2019, "volume": "167", "pages": "641-644", "doi": "10.1007/s10517-019-04588-9", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/31625062/", "doiUrl": "https://doi.org/10.1007/s10517-019-04588-9", "design": "Animal study", "whatItMeasured": "Measured object-recognition memory and BDNF content in brain structures of rats after long-term ethanol exposure.", "corrections": [], "citedOnCompounds": [ "selank" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/selank/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/selank/" } }, { "pmid": "31031702", "title": "The Discovery and Development of Liraglutide and Semaglutide.", "authors": [ "Knudsen LB", "Lau J" ], "journal": "Frontiers in endocrinology", "journalAbbreviation": "Front Endocrinol (Lausanne)", "year": 2019, "volume": "10", "pages": "155", "doi": "10.3389/fendo.2019.00155", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/31031702/", "doiUrl": "https://doi.org/10.3389/fendo.2019.00155", "design": "Review", "whatItMeasured": "Historical review of the discovery and development of liraglutide and semaglutide.", "corrections": [], "citedOnCompounds": [ "semaglutide" ], "pageUrl": { "us": 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"https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ghk-cu/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ghk-cu/" } }, { "pmid": "29983246", "title": "The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress.", "authors": [ "Kim KH", "Son JM", "Benayoun BA", "Lee C" ], "journal": "Cell metabolism", "journalAbbreviation": "Cell Metab", "year": 2018, "volume": "28", "pages": "516-524.e7", "doi": "10.1016/j.cmet.2018.06.008", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/29983246/", "doiUrl": "https://doi.org/10.1016/j.cmet.2018.06.008", "design": "In vitro and animal study", "whatItMeasured": "Showed that MOTS-c translocates to the nucleus under metabolic stress and regulates nuclear gene expression.", "corrections": [], "citedOnCompounds": [ "mots-c" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/mots-c/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/mots-c/" } }, { "pmid": "29567599", "title": "Vitamin C-linker-conjugated tripeptide AHK stimulates BMP-2-induced osteogenic differentiation of mouse myoblast C2C12 cells.", "authors": [ "Jung JI", "Park KY", "Lee Y", "Park M", "Kim J" ], "journal": "Differentiation; research in biological diversity", "journalAbbreviation": "Differentiation", "year": 2018, "volume": "101", "pages": "1-7", "doi": "10.1016/j.diff.2018.03.001", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/29567599/", "doiUrl": "https://doi.org/10.1016/j.diff.2018.03.001", "design": "In vitro", "whatItMeasured": "Examined a vitamin C-linked conjugate of the AHK tripeptide (not the copper complex) on osteoblast differentiation in a cell culture model.", "corrections": [], "citedOnCompounds": [ "ahk-cu" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ahk-cu/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ahk-cu/" } }, { "pmid": "29466332", "title": "Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.", "authors": [ "Liang YL", "Khoshouei M", "Glukhova A", "Furness SGB", "Zhao P", "Clydesdale L", "Koole C", "Truong TT", "Thal DM", "Lei S", "Radjainia M", "Danev R", "Baumeister W", "Wang MW", "Miller LJ", "Christopoulos A", "Sexton PM", "Wootten D" ], "journal": "Nature", "journalAbbreviation": "Nature", "year": 2018, "volume": "555", "pages": "121-125", "doi": "10.1038/nature25773", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/29466332/", "doiUrl": "https://doi.org/10.1038/nature25773", "design": "Structural biology", "whatItMeasured": "Cryo-EM structure of the human GLP-1 receptor and Gs complex with the biased peptide agonist exendin-P5.", "corrections": [], "citedOnCompounds": [ "semaglutide" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/semaglutide/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/semaglutide/" } }, { "pmid": "29155147", "title": "Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice.", "authors": [ "Neelakantan H", "Vance V", "Wetzel MD", "Wang HL", "McHardy SF", "Finnerty CC", "Hommel JD", "Watowich SJ" ], "journal": "Biochemical pharmacology", "journalAbbreviation": "Biochem Pharmacol", "year": 2018, "volume": "147", "pages": "141-152", "doi": "10.1016/j.bcp.2017.11.007", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/29155147/", "doiUrl": "https://doi.org/10.1016/j.bcp.2017.11.007", "design": "In vitro and animal study", "whatItMeasured": "Tested membrane-permeable methylquinolinium NNMT inhibitors in cell culture and in diet-induced obese mice.", "corrections": [], "citedOnCompounds": [ "5-amino-1mq" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/5-amino-1mq/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/5-amino-1mq/" } }, { "pmid": "28702721", "title": "Peptides semax and selank affect the behavior of rats with 6-OHDA induced PD-like parkinsonism.", "authors": [ "Slominsky PA", "Shadrina MI", "Kolomin TA", "Stavrovskaya AV", "Filatova EV", "Andreeva LA", "Illarioshkin SN", "Myasoedov NF" ], "journal": "Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections", "journalAbbreviation": "Dokl Biol Sci", "year": 2017, "volume": "474", "pages": "106-109", "doi": "10.1134/S0012496617030048", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/28702721/", "doiUrl": "https://doi.org/10.1134/S0012496617030048", "design": "Animal study", "whatItMeasured": "Measured behaviour in a rat model of parkinsonism after Semax and Selank.", "corrections": [], "citedOnCompounds": [ "selank" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/selank/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/selank/" } }, { "pmid": "28562585", "title": "Crystal structure of the GLP-1 receptor bound to a peptide agonist.", "authors": [ "Jazayeri A", "Rappas M", "Brown AJH", "Kean J", "Errey JC", "Robertson NJ", "Fiez-Vandal C", "Andrews SP", "Congreve M", "Bortolato A", "Mason JS", "Baig AH", "Teobald I", "Doré AS", "Weir M", "Cooke RM", "Marshall FH" ], "journal": "Nature", "journalAbbreviation": "Nature", "year": 2017, "volume": "546", "pages": "254-258", "doi": "10.1038/nature22800", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/28562585/", "doiUrl": "https://doi.org/10.1038/nature22800", "design": "Structural biology", "whatItMeasured": "Crystal structure of the full-length GLP-1 receptor bound to a truncated peptide agonist.", "corrections": [ { "kind": "ErratumIn", "source": "Nature. 2017 Aug 3;548(7665):122. doi: 10.1038/nature23311.", "pmid": "28700581" } ], "citedOnCompounds": [ "semaglutide" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/semaglutide/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/semaglutide/" } }, { "pmid": "28548833", "title": "Structure-Activity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase.", "authors": [ "Neelakantan H", "Wang HY", "Vance V", "Hommel JD", "McHardy SF", "Watowich SJ" ], "journal": "Journal of medicinal chemistry", "journalAbbreviation": "J Med Chem", "year": 2017, "volume": "60", "pages": "5015-5028", "doi": "10.1021/acs.jmedchem.7b00389", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/28548833/", "doiUrl": "https://doi.org/10.1021/acs.jmedchem.7b00389", "design": "Chemistry and in vitro study", "whatItMeasured": "Structure-activity relationships of small-molecule NNMT inhibitors, identifying N-methylquinolinium scaffolds with low micromolar inhibition (the scaffold class of 5-amino-1MQ).", "corrections": [], "citedOnCompounds": [ "5-amino-1mq" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/5-amino-1mq/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/5-amino-1mq/" } }, { "pmid": "28323117", "title": "Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species.", "authors": [ "Jensen L", "Helleberg H", "Roffel A", "van Lier JJ", "Bjørnsdottir I", "Pedersen PJ", "Rowe E", "Derving Karsbøl J", "Pedersen ML" ], "journal": "European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences", "journalAbbreviation": "Eur J Pharm Sci", "year": 2017, "volume": "104", "pages": "31-41", "doi": "10.1016/j.ejps.2017.03.020", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/28323117/", "doiUrl": "https://doi.org/10.1016/j.ejps.2017.03.020", "design": "Human study", "whatItMeasured": "Absorption, metabolism and excretion of radiolabelled semaglutide in healthy human subjects, compared with rat and monkey data.", "corrections": [], "citedOnCompounds": [ "semaglutide" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/semaglutide/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/semaglutide/" } }, { "pmid": "27847966", "title": "Therapeutic potential of pro-angiogenic BPC157 is associated with VEGFR2 activation and up-regulation.", "authors": [ "Hsieh MJ", "Liu HT", "Wang CN", "Huang HY", "Lin Y", "Ko YS", "Wang JS", "Chang VH", "Pang JS" ], "journal": "Journal of molecular medicine (Berlin, Germany)", "journalAbbreviation": "J Mol Med (Berl)", "year": 2017, "volume": "95", "pages": "323-333", "doi": "10.1007/s00109-016-1488-y", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/27847966/", "doiUrl": "https://doi.org/10.1007/s00109-016-1488-y", "design": "In vitro and animal study", "whatItMeasured": "Examined vessel formation in the chick chorioallantoic membrane and endothelial tube formation assays, and VEGFR2 expression and activation.", "corrections": [], "citedOnCompounds": [ "bpc-157" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/bpc-157/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/bpc-157/" } }, { "pmid": "27216708", "title": "MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism.", "authors": [ "Lee C", "Kim KH", "Cohen P" ], "journal": "Free radical biology & medicine", "journalAbbreviation": "Free Radic Biol Med", "year": 2016, "volume": "100", "pages": "182-187", "doi": "10.1016/j.freeradbiomed.2016.05.015", "pubmedUrl": 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"corrections": [], "citedOnCompounds": [ "nad-plus" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/nad-plus/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/nad-plus/" } }, { "pmid": "26236730", "title": "GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.", "authors": [ "Pickart L", "Vasquez-Soltero JM", "Margolina A" ], "journal": "BioMed research international", "journalAbbreviation": "Biomed Res Int", "year": 2015, "volume": "2015", "pages": "648108", "doi": "10.1155/2015/648108", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/26236730/", "doiUrl": "https://doi.org/10.1155/2015/648108", "design": "Review", "whatItMeasured": "Review of GHK in skin biology: collagen and glycosaminoglycan synthesis, metalloproteinase modulation and copper-dependent pathways.", "corrections": [], "citedOnCompounds": [ "ghk-cu" ], "pageUrl": { "us": 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"https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/nad-plus/" } }, { "pmid": "26096650", "title": "Dual effect of Thymosin α 1 on human monocyte-derived dendritic cell in vitro stimulated with viral and bacterial toll-like receptor agonists.", "authors": [ "Giacomini E", "Severa M", "Cruciani M", "Etna MP", "Rizzo F", "Pardini M", "Scagnolari C", "Garaci E", "Coccia EM" ], "journal": "Expert opinion on biological therapy", "journalAbbreviation": "Expert Opin Biol Ther", "year": 2015, "volume": "15 Suppl 1", "pages": "S59-70", "doi": "10.1517/14712598.2015.1019460", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/26096650/", "doiUrl": "https://doi.org/10.1517/14712598.2015.1019460", "design": "In vitro", "whatItMeasured": "Measured responses of human monocyte-derived dendritic cells to toll-like receptor agonists in the presence of thymosin alpha 1.", "corrections": [], "citedOnCompounds": [ "thymosin-alpha-1" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/thymosin-alpha-1/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/thymosin-alpha-1/" } }, { "pmid": "25738459", "title": "The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.", "authors": [ "Lee C", "Zeng J", "Drew BG", "Sallam T", "Martin-Montalvo A", "Wan J", "Kim SJ", "Mehta H", "Hevener AL", "de Cabo R", "Cohen P" ], "journal": "Cell metabolism", "journalAbbreviation": "Cell Metab", "year": 2015, "volume": "21", "pages": "443-54", "doi": "10.1016/j.cmet.2015.02.009", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/25738459/", "doiUrl": "https://doi.org/10.1016/j.cmet.2015.02.009", "design": "In vitro and animal study", "whatItMeasured": "Identified the MOTS-c open reading frame in mitochondrial DNA and reported its metabolic effects in cells and mice.", "corrections": [], "citedOnCompounds": [ "mots-c" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/mots-c/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/mots-c/" } }, { "pmid": "25208511", "title": "Detection and in vitro metabolism of AOD9604.", "authors": [ "Cox HD", "Smeal SJ", "Hughes CM", "Cox JE", "Eichner D" ], "journal": "Drug testing and analysis", "journalAbbreviation": "Drug Test Anal", "year": 2015, "volume": "7", "pages": "31-8", "doi": "10.1002/dta.1715", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/25208511/", "doiUrl": "https://doi.org/10.1002/dta.1715", "design": "Analytical chemistry", "whatItMeasured": "Detection and in vitro metabolism of AOD9604 for anti-doping analysis; notes its WADA prohibition.", "corrections": [], "citedOnCompounds": [ "aod-9604" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/aod-9604/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/aod-9604/" } }, { "pmid": "25415472", "title": "Pentadecapeptide BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts.", "authors": [ "Chang CH", "Tsai WC", "Hsu YH", "Pang JH" ], "journal": "Molecules (Basel, Switzerland)", "journalAbbreviation": "Molecules", "year": 2014, "volume": "19", "pages": "19066-77", "doi": "10.3390/molecules191119066", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/25415472/", "doiUrl": "https://doi.org/10.3390/molecules191119066", "design": "In vitro", "whatItMeasured": "Examined growth hormone receptor expression in tendon fibroblasts isolated from rat Achilles tendon.", "corrections": [], "citedOnCompounds": [ "bpc-157" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/bpc-157/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/bpc-157/" } }, { "pmid": "24134698", "title": "Targeting mitochondrial cardiolipin and the cytochrome c/cardiolipin complex to promote electron transport and optimize mitochondrial ATP synthesis.", "authors": [ "Birk AV", "Chao WM", "Bracken C", "Warren JD", "Szeto HH" ], "journal": "British journal of pharmacology", "journalAbbreviation": "Br J Pharmacol", "year": 2014, "volume": "171", "pages": "2017-28", "doi": "10.1111/bph.12468", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/24134698/", "doiUrl": "https://doi.org/10.1111/bph.12468", "design": "Animal study", "whatItMeasured": "Studied SS-31 binding to cardiolipin and its effect on the cytochrome c and cardiolipin complex, electron transport and ATP synthesis.", "corrections": [], "citedOnCompounds": [ "ss-31" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ss-31/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ss-31/" } }, { "pmid": "23813215", "title": "The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin.", "authors": [ "Birk AV", "Liu S", "Soong Y", "Mills W", "Singh P", "Warren JD", "Seshan SV", "Pardee JD", "Szeto HH" ], "journal": "Journal of the American Society of Nephrology : JASN", "journalAbbreviation": "J Am Soc Nephrol", "year": 2013, "volume": "24", "pages": "1250-61", "doi": "10.1681/ASN.2012121216", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/23813215/", "doiUrl": "https://doi.org/10.1681/ASN.2012121216", "design": "Animal study", "whatItMeasured": "Studied SS-31 interaction with cardiolipin and ATP recovery in ischaemic mitochondria in a kidney model.", "corrections": [], "citedOnCompounds": [ "ss-31" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ss-31/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ss-31/" } }, { "pmid": "22995213", "title": "Glutathione synthesis.", "authors": [ "Lu SC" ], "journal": "Biochimica et biophysica acta", "journalAbbreviation": "Biochim Biophys Acta", "year": 2013, "volume": "1830", "pages": "3143-53", "doi": "10.1016/j.bbagen.2012.09.008", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/22995213/", "doiUrl": "https://doi.org/10.1016/j.bbagen.2012.09.008", "design": "Review", "whatItMeasured": "Review of glutathione biosynthesis and its regulation.", "corrections": [], "citedOnCompounds": [ "glutathione" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/glutathione/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/glutathione/" } }, { "pmid": "22666519", "title": "The human tripeptide GHK-Cu in prevention of oxidative stress and degenerative conditions of aging: implications for cognitive health.", "authors": [ "Pickart L", "Vasquez-Soltero JM", "Margolina A" ], "journal": "Oxidative medicine and cellular longevity", "journalAbbreviation": "Oxid Med Cell Longev", "year": 2012, "volume": "2012", "pages": "324832", "doi": "10.1155/2012/324832", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/22666519/", "doiUrl": "https://doi.org/10.1155/2012/324832", "design": "Review", "whatItMeasured": "Review of GHK-Cu in the context of oxidative stress, copper homeostasis and neuroinflammation.", "corrections": [], "citedOnCompounds": [ "ghk-cu" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ghk-cu/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ghk-cu/" } }, { "pmid": "22074294", "title": "Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications.", "authors": [ "Goldstein AL", "Hannappel E", "Sosne G", "Kleinman HK" ], "journal": "Expert opinion on biological therapy", "journalAbbreviation": "Expert Opin Biol Ther", "year": 2012, "volume": "12", "pages": "37-51", "doi": "10.1517/14712598.2012.634793", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/22074294/", "doiUrl": "https://doi.org/10.1517/14712598.2012.634793", "design": "Review", "whatItMeasured": "Review of thymosin beta 4 properties: actin binding, cell migration and reported tissue-repair roles.", "corrections": [], "citedOnCompounds": [ "tb-500" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/tb-500/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/tb-500/" } }, { "pmid": "21780203", "title": "X-ray and solution structures of Cu(II) GHK and Cu(II) DAHK complexes: influence on their redox properties.", "authors": [ "Hureau C", "Eury H", "Guillot R", "Bijani C", "Sayen S", "Solari PL", "Guillon E", "Faller P", "Dorlet P" ], "journal": "Chemistry (Weinheim an der Bergstrasse, Germany)", "journalAbbreviation": "Chemistry", "year": 2011, "volume": "17", "pages": "10151-60", "doi": "10.1002/chem.201100751", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/21780203/", "doiUrl": "https://doi.org/10.1002/chem.201100751", "design": "Chemistry", "whatItMeasured": "Solid-state (X-ray) and solution structures of the copper(II) complexes of GHK and DAHK, with spectroscopy of their redox properties.", "corrections": [], "citedOnCompounds": [ "ghk-cu" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ghk-cu/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ghk-cu/" } }, { "pmid": "21638136", "title": "Novel therapies targeting inner mitochondrial membrane: from discovery to clinical development.", "authors": [ "Szeto HH", "Schiller PW" ], "journal": "Pharmaceutical research", "journalAbbreviation": "Pharm Res", "year": 2011, "volume": "28", "pages": "2669-79", "doi": "10.1007/s11095-011-0476-8", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/21638136/", "doiUrl": "https://doi.org/10.1007/s11095-011-0476-8", "design": "Review", "whatItMeasured": "Review of the discovery and development of peptides targeting the inner mitochondrial membrane, including SS-31.", "corrections": [], "citedOnCompounds": [ "ss-31" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ss-31/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ss-31/" } }, { "pmid": "21030672", "title": "The promoting effect of pentadecapeptide BPC 157 on tendon healing involves tendon outgrowth, cell survival, and cell migration.", "authors": [ "Chang CH", "Tsai WC", "Lin MS", "Hsu YH", "Pang JH" ], "journal": "Journal of applied physiology (Bethesda, Md. : 1985)", "journalAbbreviation": "J Appl Physiol (1985)", "year": 2011, "volume": "110", "pages": "774-80", "doi": "10.1152/japplphysiol.00945.2010", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/21030672/", "doiUrl": "https://doi.org/10.1152/japplphysiol.00945.2010", "design": "In vitro", "whatItMeasured": "Examined tendon fibroblast outgrowth, survival and migration in cultured rat tendon cells exposed to BPC 157.", "corrections": [], "citedOnCompounds": [ "bpc-157" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/bpc-157/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/bpc-157/" } }, { "pmid": "20699109", "title": "Thymosin alpha 1: biological activities, applications and genetic engineering production.", "authors": [ "Li J", "Liu CH", "Wang FS" ], "journal": "Peptides", "journalAbbreviation": "Peptides", "year": 2010, "volume": "31", "pages": "2151-8", "doi": "10.1016/j.peptides.2010.07.026", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/20699109/", "doiUrl": "https://doi.org/10.1016/j.peptides.2010.07.026", "design": "Review", "whatItMeasured": "Review of thymosin alpha 1 effects on T cells, dendritic cells and cytokines, and of recombinant production methods.", "corrections": [], "citedOnCompounds": [ "thymosin-alpha-1" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/thymosin-alpha-1/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/thymosin-alpha-1/" } }, { "pmid": "18796312", "title": "Glutathione: overview of its protective roles, measurement, and biosynthesis.", "authors": [ "Forman HJ", "Zhang H", "Rinna A" ], "journal": "Molecular aspects of medicine", "journalAbbreviation": "Mol Aspects Med", "year": 2009, "volume": "30", "pages": "1-12", "doi": "10.1016/j.mam.2008.08.006", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/18796312/", "doiUrl": "https://doi.org/10.1016/j.mam.2008.08.006", "design": "Review", "whatItMeasured": "Overview of the protective roles, measurement and biosynthesis of glutathione.", "corrections": [], "citedOnCompounds": [ "glutathione" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/glutathione/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/glutathione/" } }, { "pmid": "18644225", "title": "The human tri-peptide GHK and tissue remodeling.", "authors": [ "Pickart L" ], "journal": "Journal of biomaterials science. Polymer edition", "journalAbbreviation": "J Biomater Sci Polym Ed", "year": 2008, "volume": "19", "pages": "969-88", "doi": "10.1163/156856208784909435", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/18644225/", "doiUrl": "https://doi.org/10.1163/156856208784909435", "design": "Review", "whatItMeasured": "Review of remodeling-related processes attributed to GHK and GHK-Cu, including copper binding and extracellular-matrix turnover.", "corrections": [], "citedOnCompounds": [ "ghk-cu" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ghk-cu/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ghk-cu/" } }, { "pmid": "18092346", "title": "Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease.", "authors": [ "Kannengiesser K", "Maaser C", "Heidemann J", "Luegering A", "Ross M", "Brzoska T", "Bohm M", "Luger TA", "Domschke W", "Kucharzik T" ], "journal": "Inflammatory bowel diseases", "journalAbbreviation": "Inflamm Bowel Dis", "year": 2008, "volume": "14", "pages": "324-31", "doi": "10.1002/ibd.20334", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/18092346/", "doiUrl": "https://doi.org/10.1002/ibd.20334", "design": "Animal study", "whatItMeasured": "Tested KPV in murine models of inflammatory bowel disease.", "corrections": [], "citedOnCompounds": [ "kpv" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/kpv/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/kpv/" } }, { "pmid": "18061177", "title": "PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.", "authors": [ "Dalmasso G", "Charrier-Hisamuddin L", "Nguyen HT", "Yan Y", "Sitaraman S", "Merlin D" ], "journal": "Gastroenterology", "journalAbbreviation": "Gastroenterology", "year": 2008, "volume": "134", "pages": "166-78", "doi": "10.1053/j.gastro.2007.10.026", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/18061177/", "doiUrl": "https://doi.org/10.1053/j.gastro.2007.10.026", "design": "In vitro and animal study", "whatItMeasured": "Examined whether KPV activity depends on the PepT1 peptide transporter in intestinal epithelial and immune cells and in mouse colitis.", "corrections": [], "citedOnCompounds": [ "kpv" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/kpv/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/kpv/" } }, { "pmid": "17703734", "title": "The effect of tripeptide-copper complex on human hair growth in vitro.", "authors": [ "Pyo HK", "Yoo HG", "Won CH", "Lee SH", "Kang YJ", "Eun HC", "Cho KH", "Kim KH" ], "journal": "Archives of pharmacal research", "journalAbbreviation": "Arch Pharm Res", "year": 2007, "volume": "30", "pages": "834-9", "doi": "10.1007/BF02978833", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/17703734/", "doiUrl": "https://doi.org/10.1007/BF02978833", "design": "Ex vivo and in vitro study", "whatItMeasured": "Examined AHK-Cu on human hair follicles ex vivo and on cultured dermal papilla cells.", "corrections": [], "citedOnCompounds": [ "ahk-cu" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ahk-cu/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ahk-cu/" } }, { "pmid": "17600290", "title": "Thymosin alpha 1: from bench to bedside.", "authors": [ "Garaci E", "Favalli C", "Pica F", "Sinibaldi Vallebona P", "Palamara AT", "Matteucci C", "Pierimarchi P", "Serafino A", "Mastino A", "Bistoni F", "Romani L", "Rasi G" ], "journal": "Annals of the New York Academy of Sciences", "journalAbbreviation": "Ann N Y Acad Sci", "year": 2007, "volume": "1112", "pages": "225-34", "doi": "10.1196/annals.1415.044", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/17600290/", "doiUrl": "https://doi.org/10.1196/annals.1415.044", "design": "Review", "whatItMeasured": "Review of preclinical tumour models and the development path of thymosin alpha 1.", "corrections": [], "citedOnCompounds": [ "thymosin-alpha-1" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/thymosin-alpha-1/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/thymosin-alpha-1/" } }, { "pmid": "17214611", "title": "Non-clinical pharmacology and safety evaluation of TH9507, a human growth hormone-releasing factor analogue.", "authors": [ "Ferdinandi ES", "Brazeau P", "High K", "Procter B", "Fennell S", "Dubreuil P" ], "journal": "Basic & clinical pharmacology & toxicology", "journalAbbreviation": "Basic Clin Pharmacol Toxicol", "year": 2007, "volume": "100", "pages": "49-58", "doi": "10.1111/j.1742-7843.2007.00008.x", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/17214611/", "doiUrl": "https://doi.org/10.1111/j.1742-7843.2007.00008.x", "design": "Animal study", "whatItMeasured": "Non-clinical pharmacology and safety evaluation of TH9507 (tesamorelin), a growth hormone-releasing factor analogue carrying a trans-3-hexenoyl group, including plasma stability.", "corrections": [], "citedOnCompounds": [ "tesamorelin" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/tesamorelin/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/tesamorelin/" } }, { "pmid": "17077189", "title": "Studies on the physiological functions of the melanocortin system.", "authors": [ "Cone RD" ], "journal": "Endocrine reviews", "journalAbbreviation": "Endocr Rev", "year": 2006, "volume": "27", "pages": "736-49", "doi": "10.1210/er.2006-0034", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/17077189/", "doiUrl": "https://doi.org/10.1210/er.2006-0034", "design": "Review", "whatItMeasured": "Review of melanocortin system physiology: receptors, POMC-derived agonists and endogenous antagonists.", "corrections": [], "citedOnCompounds": [ "melanotan-ii" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/melanotan-ii/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/melanotan-ii/" } }, { "pmid": "17018654", "title": "Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog.", "authors": [ "Ionescu M", "Frohman LA" ], "journal": "The Journal of clinical endocrinology and metabolism", "journalAbbreviation": "J Clin Endocrinol Metab", "year": 2006, "volume": "91", "pages": "4792-7", "doi": "10.1210/jc.2006-1702", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/17018654/", "doiUrl": "https://doi.org/10.1210/jc.2006-1702", "design": "Human study", "whatItMeasured": "Examined the pulsatile pattern of growth hormone secretion in healthy adults during continuous CJC-1295 exposure (the albumin-binding form).", "corrections": [], "citedOnCompounds": [ "cjc-1295-no-dac" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/cjc-1295-no-dac/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/cjc-1295-no-dac/" } }, { "pmid": "16352683", "title": "Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.", "authors": [ "Teichman SL", "Neale A", "Lawrence B", "Gagnon C", "Castaigne JP", "Frohman LA" ], "journal": "The Journal of clinical endocrinology and metabolism", "journalAbbreviation": "J Clin Endocrinol Metab", "year": 2006, "volume": "91", "pages": "799-805", "doi": "10.1210/jc.2005-1536", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/16352683/", "doiUrl": "https://doi.org/10.1210/jc.2005-1536", "design": "Human study", "whatItMeasured": "Randomised, placebo-controlled trials in healthy adults reporting pharmacokinetics, GH and IGF-I pharmacodynamics and safety of CJC-1295 (the albumin-binding form).", "corrections": [], "citedOnCompounds": [ "cjc-1295-no-dac" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/cjc-1295-no-dac/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/cjc-1295-no-dac/" } }, { "pmid": "16274845", "title": "Immobilized alpha-melanocyte stimulating hormone 10-13 (GKPV) inhibits tumor necrosis factor-alpha stimulated NF-kappaB activity.", "authors": [ "Kelly JM", "Moir AJ", "Carlson K", "Yang Y", "MacNeil S", "Haycock JW" ], "journal": "Peptides", "journalAbbreviation": "Peptides", "year": 2006, "volume": "27", "pages": "431-7", "doi": "10.1016/j.peptides.2005.03.062", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/16274845/", "doiUrl": "https://doi.org/10.1016/j.peptides.2005.03.062", "design": "In vitro", "whatItMeasured": "Examined intracellular signalling of an immobilised alpha-MSH 10-13 peptide in cultured cells, including TNF-alpha stimulated NF-kB activation.", "corrections": [], "citedOnCompounds": [ "kpv" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/kpv/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/kpv/" } }, { "pmid": "15817669", "title": "Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog.", "authors": [ "Jetté L", "Léger R", "Thibaudeau K", "Benquet C", "Robitaille M", "Pellerin I", "Paradis V", "van Wyk P", "Pham K", "Bridon DP" ], "journal": "Endocrinology", "journalAbbreviation": "Endocrinology", "year": 2005, "volume": "146", "pages": "3052-8", "doi": "10.1210/en.2004-1286", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/15817669/", "doiUrl": "https://doi.org/10.1210/en.2004-1286", "design": "Chemistry", "whatItMeasured": "Albumin bioconjugates of GRF(1-29): stability against peptidase degradation and activity at the GRF receptor in vitro and in vivo.", "corrections": [], "citedOnCompounds": [ "cjc-1295-no-dac" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/cjc-1295-no-dac/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/cjc-1295-no-dac/" } }, { "pmid": "15455129", "title": "Peptide promotes overcoming of the division limit in human somatic cell.", "authors": [ "Khavinson VKh", "Bondarev IE", "Butyugov AA", "Smirnova TD" ], "journal": "Bulletin of experimental biology and medicine", "journalAbbreviation": "Bull Exp Biol Med", "year": 2004, "volume": "137", "pages": "503-6", "doi": "10.1023/b:bebm.0000038164.49947.8c", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/15455129/", "doiUrl": "https://doi.org/10.1023/b:bebm.0000038164.49947.8c", "design": "In vitro", "whatItMeasured": "Studied proliferative potential and telomerase in human fetal fibroblasts exposed to epithalon.", "corrections": [], "citedOnCompounds": [ "epitalon" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/epitalon/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/epitalon/" } }, { "pmid": "15230633", "title": "Pralmorelin: GHRP 2, GPA 748, growth hormone-releasing peptide 2, KP-102 D, KP-102 LN, KP-102D, KP-102LN.", "authors": [], "journal": "Drugs in R&D", "journalAbbreviation": "Drugs R D", "year": 2004, "volume": "5", "pages": "236-9", "doi": "10.2165/00126839-200405040-00011", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/15230633/", "doiUrl": "https://doi.org/10.2165/00126839-200405040-00011", "design": "Review", "whatItMeasured": "Drug profile of pralmorelin (GHRP-2): its origin, pharmacology and development history.", "corrections": [], "citedOnCompounds": [ "ghrp-2" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ghrp-2/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ghrp-2/" } }, { "pmid": "15178689", "title": "Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling, oxidative cell death, and reperfusion injury.", "authors": [ "Zhao K", "Zhao GM", "Wu D", "Soong Y", "Birk AV", "Schiller PW", "Szeto HH" ], "journal": "The Journal of biological chemistry", "journalAbbreviation": "J Biol Chem", "year": 2004, "volume": "279", "pages": "34682-90", "doi": "10.1074/jbc.M402999200", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/15178689/", "doiUrl": "https://doi.org/10.1074/jbc.M402999200", "design": "In vitro and animal study", "whatItMeasured": "Tested cell-permeable, mitochondria-targeted peptide antioxidants on mitochondrial swelling, cytochrome c release and oxidative cell death.", "corrections": [], "citedOnCompounds": [ "ss-31" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ss-31/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ss-31/" } }, { "pmid": "14573733", "title": "The GPR54 gene as a regulator of puberty.", "authors": [ "Seminara SB", "Messager S", "Chatzidaki EE", "Thresher RR", "Acierno JS", "Shagoury JK", "Bo-Abbas Y", "Kuohung W", "Schwinof KM", "Hendrick AG", "Zahn D", "Dixon J", "Kaiser UB", "Slaugenhaupt SA", "Gusella JF", "O'Rahilly S", "Carlton MB", "Crowley WF", "Aparicio SA", "Colledge WH" ], "journal": "The New England journal of medicine", "journalAbbreviation": "N Engl J Med", "year": 2003, "volume": "349", "pages": "1614-27", "doi": "10.1056/NEJMoa035322", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/14573733/", "doiUrl": "https://doi.org/10.1056/NEJMoa035322", "design": "Human genetics and animal study", "whatItMeasured": "Genetic study in a human family and in mice linking GPR54 to the onset of puberty.", "corrections": [], "citedOnCompounds": [ "kisspeptin-10" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/kisspeptin-10/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/kisspeptin-10/" } }, { "pmid": "14501183", "title": "Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.", "authors": [ "Anisimov VN", "Khavinson VKh", "Popovich IG", "Zabezhinski MA", "Alimova IN", "Rosenfeld SV", "Zavarzina NY", "Semenchenko AV", "Yashin AI" ], "journal": "Biogerontology", "journalAbbreviation": "Biogerontology", "year": 2003, "volume": "4", "pages": "193-202", "doi": "10.1023/a:1025114230714", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/14501183/", "doiUrl": "https://doi.org/10.1023/a:1025114230714", "design": "Animal study", "whatItMeasured": "Lifelong study in female mice of epitalon on biomarkers of ageing, lifespan and spontaneous tumour incidence.", "corrections": [], "citedOnCompounds": [ "epitalon" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/epitalon/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/epitalon/" } }, { "pmid": "14500546", "title": "The actin binding site on thymosin beta4 promotes angiogenesis.", "authors": [ "Philp D", "Huff T", "Gho YS", "Hannappel E", "Kleinman HK" ], "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "journalAbbreviation": "FASEB J", "year": 2003, "volume": "17", "pages": "2103-5", "doi": "10.1096/fj.03-0121fje", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/14500546/", "doiUrl": "https://doi.org/10.1096/fj.03-0121fje", "design": "In vitro and animal study", "whatItMeasured": "Mapped the actin-binding region of thymosin beta 4 and tested its angiogenic activity in endothelial-cell and tissue assays.", "corrections": [], "citedOnCompounds": [ "tb-500" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/tb-500/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/tb-500/" } }, { "pmid": "12851308", "title": "New insights into the functions of alpha-MSH and related peptides in the immune system.", "authors": [ "Luger TA", "Scholzen TE", "Brzoska T", "Böhm M" ], "journal": "Annals of the New York Academy of Sciences", "journalAbbreviation": "Ann N Y Acad Sci", "year": 2003, "volume": "994", "pages": "133-40", "doi": "10.1111/j.1749-6632.2003.tb03172.x", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/12851308/", "doiUrl": "https://doi.org/10.1111/j.1749-6632.2003.tb03172.x", "design": "Review", "whatItMeasured": "Review of alpha-MSH and related peptides in immunity and inflammation, including receptor expression on immune cells.", "corrections": [], "citedOnCompounds": [ "kpv" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/kpv/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/kpv/" } }, { "pmid": "12750433", "title": "Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides.", "authors": [ "Getting SJ", "Schiöth HB", "Perretti M" ], "journal": "The Journal of pharmacology and experimental therapeutics", "journalAbbreviation": "J Pharmacol Exp Ther", "year": 2003, "volume": "306", "pages": "631-7", "doi": "10.1124/jpet.103.051623", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/12750433/", "doiUrl": "https://doi.org/10.1124/jpet.103.051623", "design": "Animal study", "whatItMeasured": "Compared KPV with other melanocortin peptides in a mouse model of crystal-induced peritonitis.", "corrections": [], "citedOnCompounds": [ "kpv" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/kpv/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/kpv/" } }, { "pmid": "11713213", "title": "The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice.", "authors": [ "Heffernan M", "Summers RJ", "Thorburn A", "Ogru E", "Gianello R", "Jiang WJ", "Ng FM" ], "journal": "Endocrinology", "journalAbbreviation": "Endocrinology", "year": 2001, "volume": "142", "pages": "5182-9", "doi": "10.1210/endo.142.12.8522", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/11713213/", "doiUrl": "https://doi.org/10.1210/endo.142.12.8522", "design": "Animal study", "whatItMeasured": "Studied the beta-adrenergic pathway and lipid metabolism in rodents treated with human growth hormone or AOD9604.", "corrections": [], "citedOnCompounds": [ "aod-9604" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/aod-9604/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/aod-9604/" } }, { "pmid": "11457843", "title": "The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.", "authors": [ "Kotani M", "Detheux M", "Vandenbogaerde A", "Communi D", "Vanderwinden JM", "Le Poul E", "Brézillon S", "Tyldesley R", "Suarez-Huerta N", "Vandeput F", "Blanpain C", "Schiffmann SN", "Vassart G", "Parmentier M" ], "journal": "The Journal of biological chemistry", "journalAbbreviation": "J Biol Chem", "year": 2001, "volume": "276", "pages": "34631-6", "doi": "10.1074/jbc.M104847200", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/11457843/", "doiUrl": "https://doi.org/10.1074/jbc.M104847200", "design": "Receptor biology", "whatItMeasured": "Isolation of kisspeptins from human placenta as ligands of GPR54, with receptor binding and signalling in cells.", "corrections": [], "citedOnCompounds": [ "kisspeptin-10" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/kisspeptin-10/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/kisspeptin-10/" } }, { "pmid": "11387329", "title": "AXOR12, a novel human G protein-coupled receptor, activated by the peptide KiSS-1.", "authors": [ "Muir AI", "Chamberlain L", "Elshourbagy NA", "Michalovich D", "Moore DJ", "Calamari A", "Szekeres PG", "Sarau HM", "Chambers JK", "Murdock P", "Steplewski K", "Shabon U", "Miller JE", "Middleton SE", "Darker JG", "Larminie CG", "Wilson S", "Bergsma DJ", "Emson P", "Faull R", "Philpott KL", "Harrison DC" ], "journal": "The Journal of biological chemistry", "journalAbbreviation": "J Biol Chem", "year": 2001, "volume": "276", "pages": "28969-75", "doi": "10.1074/jbc.M102743200", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/11387329/", "doiUrl": "https://doi.org/10.1074/jbc.M102743200", "design": "Receptor biology", "whatItMeasured": "Cloned the human receptor AXOR12 (GPR54) and showed its activation by KiSS-1 derived peptides.", "corrections": [], "citedOnCompounds": [ "kisspeptin-10" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/kisspeptin-10/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/kisspeptin-10/" } }, { "pmid": "11385580", "title": "Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.", "authors": [ "Ohtaki T", "Shintani Y", "Honda S", "Matsumoto H", "Hori A", "Kanehashi K", "Terao Y", "Kumano S", "Takatsu Y", "Masuda Y", "Ishibashi Y", "Watanabe T", "Asada M", "Yamada T", "Suenaga M", "Kitada C", "Usuki S", "Kurokawa T", "Onda H", "Nishimura O", "Fujino M" ], "journal": "Nature", "journalAbbreviation": "Nature", "year": 2001, "volume": "411", "pages": "613-7", "doi": "10.1038/35079135", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/11385580/", "doiUrl": "https://doi.org/10.1038/35079135", "design": "Receptor biology", "whatItMeasured": "Identified the KiSS-1 gene product peptide as the ligand of an orphan G-protein-coupled receptor and measured receptor activation.", "corrections": [], "citedOnCompounds": [ "kisspeptin-10" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/kisspeptin-10/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/kisspeptin-10/" } }, { "pmid": "11146367", "title": "Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone.", "authors": [ "Ng FM", "Sun J", "Sharma L", "Libinaka R", "Jiang WJ", "Gianello R" ], "journal": "Hormone research", "journalAbbreviation": "Horm Res", "year": 2000, "volume": "53", "pages": "274-8", "doi": "10.1159/000053183", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/11146367/", "doiUrl": "https://doi.org/10.1159/000053183", "design": "Animal study", "whatItMeasured": "Studied metabolic actions of AOD9604 in obese Zucker rats, including adipose tissue changes.", "corrections": [], "citedOnCompounds": [ "aod-9604" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/aod-9604/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/aod-9604/" } }, { "pmid": "10828840", "title": "The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats.", "authors": [ "Svensson J", "Lall S", "Dickson SL", "Bengtsson BA", "Rømer J", "Ahnfelt-Rønne I", "Ohlsson C", "Jansson JO" ], "journal": "The Journal of endocrinology", "journalAbbreviation": "J Endocrinol", "year": 2000, "volume": "165", "pages": "569-77", "doi": "10.1677/joe.0.1650569", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/10828840/", "doiUrl": "https://doi.org/10.1677/joe.0.1650569", "design": "Animal study", "whatItMeasured": "Measured bone mineral content in young adult female rats exposed to ipamorelin or GHRP-6.", "corrections": [], "citedOnCompounds": [ "ipamorelin" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ipamorelin/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ipamorelin/" } }, { "pmid": "10604470", "title": "Ghrelin is a growth-hormone-releasing acylated peptide from stomach.", "authors": [ "Kojima M", "Hosoda H", "Date Y", "Nakazato M", "Matsuo H", "Kangawa K" ], "journal": "Nature", "journalAbbreviation": "Nature", "year": 1999, "volume": "402", "pages": "656-60", "doi": "10.1038/45230", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/10604470/", "doiUrl": "https://doi.org/10.1038/45230", "design": "Receptor biology", "whatItMeasured": "Purification of ghrelin from stomach as the endogenous ligand of the growth hormone secretagogue receptor.", "corrections": [], "citedOnCompounds": [ "ipamorelin" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ipamorelin/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ipamorelin/" } }, { "pmid": "10496658", "title": "Pharmacokinetic-pharmacodynamic modeling of ipamorelin, a growth hormone releasing peptide, in human volunteers.", "authors": [ "Gobburu JV", "Agersø H", "Jusko WJ", "Ynddal L" ], "journal": "Pharmaceutical research", "journalAbbreviation": "Pharm Res", "year": 1999, "volume": "16", "pages": "1412-6", "doi": "10.1023/a:1018955126402", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/10496658/", "doiUrl": "https://doi.org/10.1023/a:1018955126402", "design": "Human study", "whatItMeasured": "Pharmacokinetic and pharmacodynamic modelling of ipamorelin and growth hormone concentrations in healthy volunteers.", "corrections": [], "citedOnCompounds": [ "ipamorelin" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ipamorelin/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ipamorelin/" } }, { "pmid": "10469335", "title": "Thymosin beta4 accelerates wound healing.", "authors": [ "Malinda KM", "Sidhu GS", "Mani H", "Banaudha K", "Maheshwari RK", "Goldstein AL", "Kleinman HK" ], "journal": "The Journal of investigative dermatology", "journalAbbreviation": "J Invest Dermatol", "year": 1999, "volume": "113", "pages": "364-8", "doi": "10.1046/j.1523-1747.1999.00708.x", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/10469335/", "doiUrl": "https://doi.org/10.1046/j.1523-1747.1999.00708.x", "design": "Animal study", "whatItMeasured": "Measured wound re-epithelialisation and contraction in a rat full-thickness wound model.", "corrections": [], "citedOnCompounds": [ "tb-500" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/tb-500/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/tb-500/" } }, { "pmid": "10373343", "title": "Ipamorelin, a new growth-hormone-releasing peptide, induces longitudinal bone growth in rats.", "authors": [ "Johansen PB", "Nowak J", "Skjaerbaek C", "Flyvbjerg A", "Andreassen TT", "Wilken M", "Orskov H" ], "journal": "Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society", "journalAbbreviation": "Growth Horm IGF Res", "year": 1999, "volume": "9", "pages": "106-13", "doi": "10.1054/ghir.1999.9998", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/10373343/", "doiUrl": "https://doi.org/10.1054/ghir.1999.9998", "design": "Animal study", "whatItMeasured": "Measured longitudinal bone growth rate, body weight and growth hormone release in adult female rats.", "corrections": [], "citedOnCompounds": [ "ipamorelin" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ipamorelin/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ipamorelin/" } }, { "pmid": "9849822", "title": "Ipamorelin, the first selective growth hormone secretagogue.", "authors": [ "Raun K", "Hansen BS", "Johansen NL", "Thøgersen H", "Madsen K", "Ankersen M", "Andersen PH" ], "journal": "European journal of endocrinology", "journalAbbreviation": "Eur J Endocrinol", "year": 1998, "volume": "139", "pages": "552-61", "doi": "10.1530/eje.0.1390552", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/9849822/", "doiUrl": "https://doi.org/10.1530/eje.0.1390552", "design": "In vitro and animal study", "whatItMeasured": "Describes the pharmacology of ipamorelin: growth hormone release in vitro and in animals, and selectivity against other pituitary hormones.", "corrections": [], "citedOnCompounds": [ "ipamorelin" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ipamorelin/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ipamorelin/" } }, { "pmid": "9733495", "title": "A new series of highly potent growth hormone-releasing peptides derived from ipamorelin.", "authors": [ "Ankersen M", "Johansen NL", "Madsen K", "Hansen BS", "Raun K", "Nielsen KK", "Thogersen H", "Hansen TK", "Peschke B", "Lau J", "Lundt BF", "Andersen PH" ], "journal": "Journal of medicinal chemistry", "journalAbbreviation": "J Med Chem", "year": 1998, "volume": "41", "pages": "3699-704", "doi": "10.1021/jm9801962", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/9733495/", "doiUrl": "https://doi.org/10.1021/jm9801962", "design": "Chemistry", "whatItMeasured": "Medicinal-chemistry series derived from ipamorelin, with growth hormone release measured in vitro and in animals.", "corrections": [], "citedOnCompounds": [ "ipamorelin" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ipamorelin/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ipamorelin/" } }, { "pmid": "8993403", "title": "The growth-hormone-releasing hormone receptor: signal transduction, gene expression, and physiological function in growth regulation.", "authors": [ "Mayo KE", "Miller TL", "DeAlmeida V", "Zheng J", "Godfrey PA" ], "journal": "Annals of the New York Academy of Sciences", "journalAbbreviation": "Ann N Y Acad Sci", "year": 1996, "volume": "805", "pages": "184-203", "doi": "10.1111/j.1749-6632.1996.tb17483.x", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/8993403/", "doiUrl": "https://doi.org/10.1111/j.1749-6632.1996.tb17483.x", "design": "Review", "whatItMeasured": "Review of GHRH receptor signal transduction, gene expression and physiological function.", "corrections": [], "citedOnCompounds": [ "cjc-1295-no-dac", "sermorelin", "tesamorelin" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/cjc-1295-no-dac/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/cjc-1295-no-dac/" } }, { "pmid": "8950613", "title": "Growth hormone-releasing peptides: clinical and basic aspects.", "authors": [ "Argente J", "García-Segura LM", "Pozo J", "Chowen JA" ], "journal": "Hormone research", "journalAbbreviation": "Horm Res", "year": 1996, "volume": "46", "pages": "155-9", "doi": "10.1159/000185015", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/8950613/", "doiUrl": "https://doi.org/10.1159/000185015", "design": "Review", "whatItMeasured": "Review of synthetic growth hormone-releasing peptides: clinical and basic aspects in animals and humans.", "corrections": [], "citedOnCompounds": [ "sermorelin" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/sermorelin/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/sermorelin/" } }, { "pmid": "8688086", "title": "A receptor in pituitary and hypothalamus that functions in growth hormone release.", "authors": [ "Howard AD", "Feighner SD", "Cully DF", "Arena JP", "Liberator PA", "Rosenblum CI", "Hamelin M", "Hreniuk DL", "Palyha OC", "Anderson J", "Paress PS", "Diaz C", "Chou M", "Liu KK", "McKee KK", "Pong SS", "Chaung LY", "Elbrecht A", "Dashkevicz M", "Heavens R", "Rigby M", "Sirinathsinghji DJ", "Dean DC", "Melillo DG", "Patchett AA", "Nargund R", "Griffin PR", "DeMartino JA", "Gupta SK", "Schaeffer JM", "Smith RG", "Van der Ploeg LH" ], "journal": "Science (New York, N.Y.)", "journalAbbreviation": "Science", "year": 1996, "volume": "273", "pages": "974-7", "doi": "10.1126/science.273.5277.974", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/8688086/", "doiUrl": "https://doi.org/10.1126/science.273.5277.974", "design": "Receptor biology", "whatItMeasured": "Cloning of the pituitary and hypothalamic G-protein-coupled receptor targeted by growth hormone secretagogues.", "corrections": [], "citedOnCompounds": [ "ipamorelin", "ghrp-2" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ipamorelin/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ipamorelin/" } }, { "pmid": "8637402", "title": "Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.", "authors": [ "Dorr RT", "Lines R", "Levine N", "Brooks C", "Xiang L", "Hruby VJ", "Hadley ME" ], "journal": "Life sciences", "journalAbbreviation": "Life Sci", "year": 1996, "volume": "58", "pages": "1777-84", "doi": "10.1016/0024-3205(96)00160-9", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/8637402/", "doiUrl": "https://doi.org/10.1016/0024-3205(96)00160-9", "design": "Human study", "whatItMeasured": "Pilot phase I study of melanotan-II in a small group of healthy volunteers (1996).", "corrections": [], "citedOnCompounds": [ "melanotan-ii" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/melanotan-ii/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/melanotan-ii/" } }, { "pmid": "1333056", "title": "Molecular cloning and expression of a pituitary-specific receptor for growth hormone-releasing hormone.", "authors": [ "Mayo KE" ], "journal": "Molecular endocrinology (Baltimore, Md.)", "journalAbbreviation": "Mol Endocrinol", "year": 1992, "volume": "6", "pages": "1734-44", "doi": "10.1210/mend.6.10.1333056", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/1333056/", "doiUrl": "https://doi.org/10.1210/mend.6.10.1333056", "design": "Receptor biology", "whatItMeasured": "Cloning and expression of the pituitary GHRH receptor, with ligand binding and cAMP production in transfected cells.", "corrections": [], "citedOnCompounds": [ "cjc-1295-no-dac", "sermorelin" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/cjc-1295-no-dac/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/cjc-1295-no-dac/" } }, { "pmid": "3169264", "title": "Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+.", "authors": [ "Maquart FX", "Pickart L", "Laurent M", "Gillery P", "Monboisse JC", "Borel JP" ], "journal": "FEBS letters", "journalAbbreviation": "FEBS Lett", "year": 1988, "volume": "238", "pages": "343-6", "doi": "10.1016/0014-5793(88)80509-x", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/3169264/", "doiUrl": "https://doi.org/10.1016/0014-5793(88)80509-x", "design": "In vitro", "whatItMeasured": "Measured collagen synthesis in cultured fibroblasts exposed to the GHK-Cu complex over a range of concentrations.", "corrections": [], "citedOnCompounds": [ "ghk-cu" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/ghk-cu/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/ghk-cu/" } }, { "pmid": "3628078", "title": "Degradation and aggregation of delta sleep-inducing peptide (DSIP) and two analogs in plasma and serum.", "authors": [ "Graf MV", "Saegesser B", "Schoenenberger GA" ], "journal": "Peptides", "journalAbbreviation": "Peptides", "year": 1987, "volume": "8", "pages": "599-603", "doi": "10.1016/0196-9781(87)90031-3", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/3628078/", "doiUrl": "https://doi.org/10.1016/0196-9781(87)90031-3", "design": "In vitro", "whatItMeasured": "Measured degradation and aggregation of DSIP and two analogues in human and rat blood plasma and serum.", "corrections": [], "citedOnCompounds": [ "dsip" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/dsip/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/dsip/" } }, { "pmid": "3550726", "title": "Delta-sleep-inducing peptide (DSIP): an update.", "authors": [ "Graf MV", "Kastin AJ" ], "journal": "Peptides", "journalAbbreviation": "Peptides", "year": 1986, "volume": "7", "pages": "1165-87", "doi": "10.1016/0196-9781(86)90148-8", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/3550726/", "doiUrl": "https://doi.org/10.1016/0196-9781(86)90148-8", "design": "Review", "whatItMeasured": "Update review of the DSIP literature on sleep and other effects in animals and humans.", "corrections": [], "citedOnCompounds": [ "dsip" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/dsip/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/dsip/" } }, { "pmid": "6137189", "title": "Glutathione.", "authors": [ "Meister A", "Anderson ME" ], "journal": "Annual review of biochemistry", "journalAbbreviation": "Annu Rev Biochem", "year": 1983, "volume": "52", "pages": "711-60", "doi": "10.1146/annurev.bi.52.070183.003431", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/6137189/", "doiUrl": "https://doi.org/10.1146/annurev.bi.52.070183.003431", "design": "Review", "whatItMeasured": "Annual Review of Biochemistry chapter on glutathione.", "corrections": [], "citedOnCompounds": [ "glutathione" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/glutathione/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/glutathione/" } }, { "pmid": "6812220", "title": "Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly.", "authors": [ "Guillemin R", "Brazeau P", "Böhlen P", "Esch F", "Ling N", "Wehrenberg WB" ], "journal": "Science (New York, N.Y.)", "journalAbbreviation": "Science", "year": 1982, "volume": "218", "pages": "585-7", "doi": "10.1126/science.6812220", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/6812220/", "doiUrl": "https://doi.org/10.1126/science.6812220", "design": "Chemistry", "whatItMeasured": "Isolation and amino-acid sequence of a 44-residue growth hormone-releasing peptide from a human pancreatic tumour, with a synthetic replicate.", "corrections": [], "citedOnCompounds": [ "sermorelin" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/sermorelin/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/sermorelin/" } }, { "pmid": "6292724", "title": "Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour.", "authors": [ "Rivier J", "Spiess J", "Thorner M", "Vale W" ], "journal": "Nature", "journalAbbreviation": "Nature", "year": 1982, "volume": "300", "pages": "276-8", "doi": "10.1038/300276a0", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/6292724/", "doiUrl": "https://doi.org/10.1038/300276a0", "design": "Chemistry", "whatItMeasured": "Isolation and characterisation of growth hormone-releasing factor from a human pancreatic islet tumour.", "corrections": [], "citedOnCompounds": [ "sermorelin" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/sermorelin/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/sermorelin/" } }, { "pmid": "568769", "title": "The delta EEG (sleep)-inducing peptide (DSIP). XI. Amino-acid analysis, sequence, synthesis and activity of the nonapeptide.", "authors": [ "Schoenenberger GA", "Maier PF", "Tobler HJ", "Wilson K", "Monnier M" ], "journal": "Pflugers Archiv : European journal of physiology", "journalAbbreviation": "Pflugers Arch", "year": 1978, "volume": "376", "pages": "119-29", "doi": "10.1007/BF00581575", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/568769/", "doiUrl": "https://doi.org/10.1007/BF00581575", "design": "Chemistry", "whatItMeasured": "Amino-acid analysis, sequence and synthesis of the nonapeptide DSIP, with activity testing.", "corrections": [], "citedOnCompounds": [ "dsip" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/dsip/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/dsip/" } }, { "pmid": "265572", "title": "Characterization of a delta-electroencephalogram (-sleep)-inducing peptide.", "authors": [ "Schoenenberger GA", "Monnier M" ], "journal": "Proceedings of the National Academy of Sciences of the United States of America", "journalAbbreviation": "Proc Natl Acad Sci U S A", "year": 1977, "volume": "74", "pages": "1282-6", "doi": "10.1073/pnas.74.3.1282", "pubmedUrl": "https://pubmed.ncbi.nlm.nih.gov/265572/", "doiUrl": "https://doi.org/10.1073/pnas.74.3.1282", "design": "Animal study and chemistry", "whatItMeasured": "Isolation of DSIP from rabbit cerebral venous blood, sequence determination and EEG tests of the peptide and analogues in rabbits.", "corrections": [], "citedOnCompounds": [ "dsip" ], "pageUrl": { "us": "https://peptency-528mygck1-wilcotds-projects.vercel.app/us/research/compounds/dsip/", "eu": "https://peptency-528mygck1-wilcotds-projects.vercel.app/eu/research/compounds/dsip/" } } ] }